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In the lymph nodes of the DO11.10 mice, the TCR transgene positive CD4∶CD8 ratio was ∼14.7 compared to ∼3.6 in the DO11.10/Itk−/− mice, a change of ∼4 fold (Fig. 4c).

In the lymph node, the ratio of CD4∶CD8 TCR transgenic T cells was 37 in the WT OT-II mice compared to 1.5 in the OT-II/Itk−/− mice, a change of 25 fold (Fig. 3c).

This resulted in a ratio of CD4∶CD8 TCR transgene positive cells of 0.7 in OT-II/Itk−/− mice, compared to 70 for the WT OT-II mice, a change of greater than 100 fold.

This resulted in a ratio of CD4∶CD8 TCR transgene positive of ∼162 in WT DO11.10 mice, compared to ∼50 for the DO11.10/Itk−/− mice, a change of ∼3 fold.

In Lor ko mice a change in the mechanical stability of the CO had been shown (Koch et al, 2000), which was similar to the defect observed in K5cre-CMVcaNrf2 mice.

Similar(55)

Radiotelemetry in unanesthetized mice revealed tachycardia in NET+/P mice without a change in blood pressure or baroreceptor sensitivity, consistent with studies of human NET A457P carriers.

This is supported by in vitro data, because neither JunB-silenced 3T3-L1 cells nor mouse embryonic fibroblasts from JunB-KO mice show a change in adipogenic potential.

No post hoc effects were found in 129P3 mice, suggesting that neither vehicle-treated nor diazepam treated mice showed a change in avoidance behaviour across the experimental period.

But in 2009, Peter Turnbaugh, a microbiologist at Harvard University, demonstrated in mice that a change in diet affected the microbiome in just a day.

In association with loss of the white adipose tissue compartment, smooth muscle actin staining is increased in glands from VDR KO mice, suggesting a change in the stromal microenviroment.

C57BL/6J mice exhibited a change in transcriptome profiles that was distinct for days 3, 5, 8, and 14 after infection.

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