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This review examines recent conceptual and methodological developments which are contributing to a paradigm shift in the study of psychopathology.

The modular structure enables scientists to use ESPResSo++ as a research platform for their own methodological developments, which at the same time allows the software to grow and acquire the most modern methods.

The methodological developments which are currently underway within the GBD update, due out in 2013, may have implications for our results.

In addition, methodological developments which incorporate thick data collection via ethnographic approaches, inductive theory development through interdisciplinary reflection and subsequent use of epidemiological surveys to verify ideas, is highly innovative and will bring new skills and knowledge.

These methodological developments, which allow to experimentally determine mRNA local characteristics at a genomic scale and at 1-nucleotide resolution, allowed us to perform the first large scale analysis on the relationship between local patterns of mRNA proxies of translation speed and protein functional features.

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On the other hand, HIA is a tool under methodological development which use is hindered due to the existing narrow biomedical perspective on the determinants of health, and to the difficulties in working in public policy-making with multisectorial and participative perspectives.

Geoelectrics is one of the most reliable prospecting tools in the field of Cultural Heritage, thanks to the technological and methodological developments in recent years, which have made it a fast target-oriented method.

Methodological developments like "pre-phasing" (which we address in the Discussion) can alleviate this concern by speeding up imputation, but existing methods still need substantial computing power to handle reference sets with thousands of haplotypes.

The studies are spread across a number of years, and during that time there have been significant methodological developments and technological improvements which have made previously complex computation within the reach of many health researchers.

Mass spectrometry is the reference method for stable isotope determination, and there have been no methodological developments in the last few decades, which have improved the accuracy or precision of deuterium analysis.

If our simple case studies motivate more evolutionists to explore a wider range of methods beyond the TOL, i.e. to explore woods and webs, for which conceptual and methodological developments are still in their infancy, rather than defaulting to a single practice, this paper will have achieved its goal.

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