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This implies methodological challenges, which should be addressed.
However, the use of QALYs in child health care poses serious methodological challenges which must be considered carefully in the search for an appropriate outcome measure [ 30, 31].
Determining causal relationships between teamworking and outcome is riddled with methodological challenges, which may partly account for the lack of empirical research regarding predictors of effectiveness [ 1].
Economic evaluation trials are facing specific methodological challenges, which are described for instance by Ramsey et al. and Tunis et al. [ 3, 5].
However, it was the process of overcoming the methodological challenges, which led to the conclusion that in this example percent low social class occupations was the most appropriate measure to use when extending cross-sectional analysis of standing balance and chair rise to life course investigation.
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This is a methodological challenge which must be overcome in reclaimed minesoils (RMS).
The three articles reviewed here engage with different on-line portals (Twitter, Flickr, and web-based collective sound maps), but encounter some similar methodological challenges for which they each develop novel solutions, thus indicating some important developments in the production of knowledge.
In entering this poorly charted territory, this study presented several methodological challenges for which we found reasonable but ad hoc solutions.
The lack of studies we found could reflect the additional methodological and ethical challenges which work in these settings and with these population groups entails.
Testing for the postulated SDD contextual effects on infection incidences is difficult due to the methodological and analytical challenges which cannot be adequately addressed within the confines of the typical single center RCCT.
Another methodological challenge, to which we'll return, concerns the deep connection between touch and exploratory action (nicely summarized in Jones and Lederman 2006).
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