Sentence examples for method of mutation from inspiring English sources

This is the method of "mutation accumulation" (MA).

Lower prevalence of BRAF mutation was reported in studies that used sequencing as the sole method of mutation analysis [ 6].

More recently next generation sequencing (NGS) has led to a hypothesis-null method of mutation identification through complete sequencing of exons at a locus in a single affected individual.

The method of mutation detection was validated by the confirmation of reported K-ras status in CRC cell lines and a good correlation between fresh-frozen and routinely fixed, paraffin-embedded tissue.

One advantage of this method of mutation discovery is that the location of the mismatch-cleaved bands in the gel image can be used to predict within 10 20 bp where mutations fall within the coding regions of the PCR fragment being screened.

A popular and low cost method of mutation detection has been the protein truncation test (PTT), where target regions of BRCA1/2 are PCR amplified, transcribed/translated in a cell-free protein synthesis system and analyzed for truncated polypeptides by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and autoradiography.

A widely recognized method of mutations detection is the use of the energy transfer through the fluorescent resonance phenomenon (FRET), which is used, for example, in analysis systems based on TaqMan-type and similar probes [ 39].

With regard to the method of mutations, we note that the particular implementation adopted here does not make any qualitative difference in the results; e.g. when r is chosen from a uniform distribution in [0,1] upon mutation, essentially the same results are obtained with the same mutation rate, μ = 0.01 (data not shown).

This method could conveniently supplement other methods of mutation detection analysis on large-scale.

The latter may reflect differences in the methods of mutation detection or the intrinsic genetic heterogeneity of HNSCCs.

The families have been comprehensively screened for germline mutation in these genes by conventional methods of mutation analysis and were found negative.