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However, the relationship between chaperonin substrates and metabolism (or the metabolic network) has not been examined until now.
Each solution, minimal metabolism cell, found through computational analysis of metabolic network has different properties that may not be captured in the model used for computational analysis.
As illustrative example, the central carbon metabolism of a genome-scale reconstructed Escherichia coli metabolic network has approximately 26 million EFM [ 9].
The cardiac metabolic network has developed a versatile system, capable of metabolizing all carbon substrates for energy production, where glucose and fatty acids (FA) are the main substrates (Fig. 2).
The metabolic network has a modular architecture, is robust to perturbations, and responds to biological stimuli and environmental conditions.
One of the difficulties is due to the fact that H2 output represents an energy loss for the cell and that microbial metabolic network has evolved for rationalization of energy use and optimization of specific growth rate.
Similar(21)
Parts of the metabolic network have been investigated on different levels to understand the key processes.
Despite the vast amount of studies, however, galactose assimilation and its interaction with other parts of the metabolic network have not been fully elucidated yet.
Several studies have shown that the modules in a metabolic network have hierarchy [ 2].
The studies of this metabolic network have been facilitated by the extensive availability of E. coli biochemical data.
In recent years, human miRNA regulated cellular networks, such as signal transduction, gene regulatory network, PIN and metabolic network, have been studied in great detail [ 5- 9].
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