Assumptions: a cell metabolic network is mainly composed of glycolysis, TCA cycle, amino acid metabolism, and product synthesis.
An important step in the reconstruction of a metabolic network is annotation of metabolites.
However, there are many situations where the reprogramming of the metabolic network is important.
An important step in the reconstruction of a metabolic network is the annotation of reconstruction components [2].
Complete manual acquisition of atom mapping data for a genome-scale metabolic network is a laborious process.
Quantification of the velocities in vivo through the branches of the metabolic network is called metabolic flux analysis.
Moreover, because most metabolic reactions are linked with disease genes, the human metabolic network is rather fragile [38].
The metabolic network is characterized by a distribution of loads far from homogeneous but nevertheless narrower than the ones associated to the other two networks.
Analysis of the dynamic response of modular sections of the central metabolic network is an important approach to determine how cells respond and adapt to carbon substrate perturbation.
In another representation, the metabolic network is built up of nodes, the substrates, which are connected to one another through links, which are the actual metabolic reactions.
In Fig. 1A, a toy metabolic network is shown.
