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Regardless of the mechanism, metabolic memory has lasted for at least 10 years.
For administration of SC, "metabolic memory" has to be considered first.
The term "metabolic memory" has been used to describe the differences in outcomes that persist or even expand after the original separation in chronic glycemia, based on treatment assignment, has disappeared.
Over the past decade, the concept of metabolic memory has described the phenomenon that hyperglycemia produces ongoing sustained damage in target tissues even after blood glucose levels are normalized [ 14].
In addition, the further separation of these outcomes during the Epidemiology of Diabetes Interventions and Complications (EDIC) study, despite the disappearance of the differences in HbA1c seen in the DCCT (metabolic memory), has been described (2).
Studies conducted over the last 15 20 years have shown that strict glycemic control after diabetes diagnosis can prevent both micro- and macrovascular complications, and the concept of metabolic memory has been emphasized (21).
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The theories justifying such involvement of vascular metabolic memory have implicated non-reversible epigenetic regulation [ 57].
Recent reports of epigenetics mechanisms in renal injury, fibrosis, inflammation, and metabolic memory have set the stage for future research in this area [ 35].
Emerged concepts in vascular metabolic memory have explained limited efficacies of antihyperglycemic treatment and its late effect in type 2 diabetes [ 56].
This is good metabolic memory and has acquired a number of synonyms including a legacy effect, glycemic memory, hyperglycemic memory, among others (1, 2).
Our study is novel in that we are comparing cells derived from non-diabetic patients to cells derived from diabetic patients with and without ulceration, whereas previous epigenetic metabolic memory studies have only compared diabetic to non-diabetic tissue 6,9,12,13,30 or hyperglycemia vs. normoglycemia.
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