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The synaptic vesicle protein that mediates membrane fusion during exocytosis also regulates the rate and extent of this process by controlling vesicle tethering.
The HIV-1 Env transmembrane subunit gp41 serves to anchor the Env protein to cellular membranes and mediate membrane fusion during virus entry into the cell (Chan and Kim, 1998).
Work over the last decades revealed that Ca2+ binding to synaptotagmin triggers release by stimulating synaptotagmin binding to a core fusion machinery composed of SNARE and SM proteins that mediates membrane fusion during exocytosis.
A similar phenomenon was reported for the R-SNARE gene SEC22 in Arabidopsis mutants (El-Kasmi et al. 2011), which show fragmentation of Golgi stacks, presumably because of blocked membrane fusion during anterograde or retrograde ER to Golgi trafficking (El-Kasmi et al. 2011).
In sporulating diploid S. cerevisiae cells only Sso1p, but not Sso2p, is needed for membrane fusion during prospore membrane formation.
Their docked conformations displayed common hydrophobic interactions with critical residues that affected membrane fusion during viral entry.
Similar(34)
SNARE proteins, however, play a ubiquitous role in vesicle-membrane fusion during neurotransmitter release in both the peripheral and central nervous systems.
Enzymatic cleavage of VAMP I/II by LC protease domain of BoNT-B results in failure of formation of SNARE protein complex and prevention of vesicle-membrane fusion during neurotransmitter release.
This same group recently reported evidence for the transient exposure of acrosomal matrix proteins in guinea pig sperm during capacitation, suggesting the occurrence of multiple membrane fusion events during the course of capacitation.
It will therefore be of interest to determine whether such potentially fusogenic vesicles are mobilised to participate in other membrane fusion events during mitosis or interphase [24].
Atg8/LC3 mediates membrane fusion events during vesicle formation and recruits cargo via LC3-interacting region (LIR) containing proteins.
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