Sentence examples for mediators of epigenetic from inspiring English sources

DNA methylation and polycomb proteins are well-known mediators of epigenetic silencing in mammalian cells.

Alterations in histone modifications appear to be primary mediators of epigenetic inheritance in cancer cells [ 39- 41].

Though not considered a classical epigenetic mechanism, the ability of microRNAs (miRNAs) to regulate gene expression has led some to consider these molecules as mediators of epigenetic change.

Together, these studies highlight the emerging role of miRNAs as mediators of epigenetic modifications that may be involved in ethanol's actions.

To use the common terminology for mediators of epigenetic regulation, cytosine variants are established by writers, bound to by readers, and removed by erasers.

Despite global hypomethylation, resistance to DNA demethylation was observed in some retrotransposon-associated and single copy regions, which are potential mediators of epigenetic memory and transgenerational inheritance in humans.

ANRIL is furthermore a mediator of epigenetic regulation [ 13].

In a recent report, Chang and colleagues identified a novel role for BRCA1 as an important mediator of epigenetic repression of an oncomiR; that is, miRNA-155 [ 9].

Despite global hypomethylation, we found regions that are variably resistant to DNA demethylation, which are potential mediators of transgenerational epigenetic inheritance.

After first demonstrating that the tissue microenvironment regulates the emergence of the malignant phenotype, regardless of the genetic changes involved, the group has recently identified the molecular mediators of this epigenetic regulation.

We speculate that MeCP2, which is one of the most important mediators of the epigenetic signal, is regulated by OR and therefore plays a key role in the differentiation processes in human breast tissues.