Sentence examples for mediator of pathological from inspiring English sources

Studies conducted over almost two decades have consistently implicated transforming growth factor-ß (TGF-ß) as a key mediator of pathological fibrosis [6].

Lipopolysaccharide (LPS), a cell component of Gram-negative bacteria, is an important mediator of pathological bone destruction associated with inflammation.

Of note is the widely accepted consideration of α7 receptor as a key mediator of pathological effects in airways of tobacco components [ 58].

Our discussion converges to the point that ROBO4 is a key mediator of pathological angiogenesis and unravelling its mechanism of action may prove it as double edged sword.

Although TGFβ is a mediator of pathological EMT, TGFβ can also suppress metastasis and is an important regulator of immune function.

Autophagy is emerging as an important mediator of pathological responses and engages in cross-talk with ROS (reactive oxygen species) and RNS (reactive nitrogen species) in both cell signalling and protein damage.

In fact, while EC metabolism is largely understudied, several of the above-mentioned metabolic pathways have been implicated as mediators of pathological angiogenesis or EC dysfunction.

However, although macrophages are emerging as indispensable for damage control and tissue remodeling following muscle injury and as principal mediators of pathological skeletal remodeling in diseases such as idiopathic inflammatory myositis (IIMs) and muscular dystrophies (MDs), the involvement of other immune cells in promoting or preventing muscle damage resolution is also emerging.

In this context, although macrophages are emerging as indispensable for damage control and tissue remodelling following muscle injury, and as principal mediators of pathological skeletal remodelling in diseases such as IIMs and dystrophies, the involvement of other immune cells in promoting or preventing muscle damage resolution is also emerging.

This may be an adaptive mechanism aimed at the detoxification of ROS, an important mediator of various pathological conditions [24].

Autophagy is an important mediator of many pathological responses.