Sentence examples for mediator of local from inspiring English sources

The tPA is the primary mediator of local intravascular fibrinolysis.

Interleukin-1β (IL-1β) is a major mediator of local inflammation present in injured joints.

In lung circulation, nitric oxide is an important mediator of local vasodilatation for matching of regional blood flows to regional ventilation (Ghofrani et al. 2006).

This finding implies that intracellular HMGB1 is released from various epidermal tumors as a result of cell necrosis cells, enabling it to act as an extracellular mediator of local inflammation.

Collectively, these observations add to a growing body of evidence indicating that RANKL does not regulate local inflammation in either AIA or CIA in rats, while further supporting the premise that RANKL is a common and important downstream mediator of local and systemic bone loss in these models [ 16, 21, 24- 26].

This result proves that Y4 receptors within the ARC are important mediators of local PP-induced c-Fos activation, and that PP action via Y4 signaling in the ARC controls POMC mRNA expression.

Pro-inflammatory cytokines, such as interleukin-1β (IL-1β), are major mediators of local inflammation and are known to be present in injured joints.

Hence, these DE genes likely represent important mediators of the local APR against E. coli in the mammary gland.

In the lung, these proteins are essential mediators of the local immune response in that they modulate the function of dendritic and T cells and facilitate the removal of pathogens by the alveolar macrophage (Sorenson et al. 2007).

In animal models of infection or local tissue injury, HMGB1 functions as a critical mediator of systemic or local inflammatory injury [ 11].

HMGB1 is a non-histone nucleosomal protein which is expressed in all mammal cells, a critical mediator of systemic and local inflammation [ 7].