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LRRK2 is a serine/threonine kinase responsible for the phosphorylation of actin crosslinkers, moesin (MSN), ezin (EZR) and radixin (RDX) (Ref. 55), as well as the eukaryotic initiation factor 4E (eIF4E -binding proteIF4E -bindinghich is a negative regulator of eIF4E-mediated protein translation and a key mediator of various stress responses.
CST has been recently identified as a mediator of various beneficial effects in animal models of sepsis.
Nitric oxide (NO), a mediator of various physiological and pathophysiological processes, is synthesized by three isozymes of nitric oxide synthase (NOS).
Because Ehd1 is modulated by several regulators, it acts as a mediator of various floral signals.
This may be an adaptive mechanism aimed at the detoxification of ROS, an important mediator of various pathological conditions [24].
In the nervous system, miRNAs can also function as important mediator of various pathological processes [ 50].
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In order to find suitable alternatives for conventional food preservatives, we focused on microbial volatile organic compounds (mVOCs), which are mediators of various interactions in nature (Effmert et al. 2012; Kanchiswamy et al. 2015).
Leukotrienes are physiological important mediators of various inflammatory and immediate hypersensitivity processes [ 46].
Akts are crucial mediators of various cellular processes, such as cell proliferation, apoptosis, regulation of the cell cycle and metabolism, and protein synthesis.
Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase1/2 (ERK1/2), and p38 MAPK, are mediators of various cellular signaling pathways in response to extracellular apoptotic stimuli and intracellular oxidative stress after transient focal cerebral ischemia [ 3, 4].
Twenty-one inflamediatorsediatorepresentativeive of various manifestations of acute inflammation were assessed over this time course in these mice.
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mediator of progesterone
mediator of worsened
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mediator of epigenetic
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