Sentence examples for mediate virus entry from inspiring English sources

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity.

For the closely related herpes simplex virus (HSV), cellular molecules have also been shown to preferentially mediate virus entry in different cell types; nectin-1 importantant for entry of HSV in neurons, while HVEM is used for entry in lymphocytes [26].

These viral factors act in concert with host proteins to mediate virus entry and to coordinate RNA replication and virus production which is coupled to lipoprotein biogenesis.

The H5N1 virus was also shown to infect nasopharyngeal and oropharyngeal epithelia, which do not express SAα-2,3Gal, suggesting that other binding sites on nasopharyngeal and oropharyngeal epithelia may be able to mediate virus entry.

ORF2 peptide-binding experiments suggested that the C-terminal region of ORF2 may mediate virus entry by binding to heat shock cognate protein 70 (HSC70) on the cell surface.

It will be of interest for the future to perform more detailed studies to elucidate which subspecies of HEV-B are most abundant in patients with inflammatory bowel disease and also which receptors that can mediate virus entry into the enteric nervous system.

The HIV gp160 envelope fusion protein is situated in the viral membrane and mediates virus entry into its host cell.

We reported previously that a small molecule named CL-385319 could inhibit H5N1 influenza virus infection by targeting hemagglutinin, the envelope protein mediating virus entry.

In vitro studies have suggested that the envelope glycoprotein (GP1,2) of EBOV mediating virus entry may also directly contribute to the viral pathogenesis, as cell surface expression of GP1,2 can induce adherent cell rounding and detachment and sterically mask some cell surface molecules, such as β1-integrin (reviewed in Ning et al., 2017).

Our data are in agreement with the recent study showing that SARS-CoV S-mediated virus entry is dependent on the sequential proteolytic cleavage of monobasic sites [27].

In an effort to directly demonstrate that airway protease mediated virus entry enhancement is due to the presence of cleavage site on the SARS spike glycoprotein, 16HBE cells were pre-incubated with wild-type (SARS-CoVpp) or mutant (R667App) pseudotypes on ice, which allowed virus attachment but not entry.