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Motivation: Complex patterns of protein phosphorylation mediate many cellular processes.
However, it must be kept in mind that transduction cascades mediate many cellular processes.
α2-adrenergic receptors (ARs) mediate many cellular actions of epinephrine and norepinephrine and inhibit their secretion from adrenal chromaffin cells.
Indeed, Gβγ dimers are known to mediate many cellular responses and signaling pathways involved in multiple aspects of cellular function.
In bacteria and archea, as well as some plants, fungi and protozoa [ 124], TCST systems mediate many cellular processes that respond to a broad range of environmental stimuli via activation of a specific histidine (or serine) kinase sensor and its cognate response regulator [ 125].
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Calmodulin is a calcium binding protein which acts as a calcium sensor [ 96] and plays an important role in mediating many cellular processes including muscle contraction [ 97, 98].
NO, a relatively stable uncharged radical that readily crosses lipid membranes, is a good inter- and intracellular trafficker in mediating many cellular responses (Crow 1997).
The transcriptional complex hypoxia-inducible factor (HIF) has emerged as a key regulator mediating many cellular responses necessary to adapt to changes in oxygen tension (reviewed in Maxwell et al, 2001; Goonewardene et al, 2002; Pugh and Ratcliffe, 2003).
The p75NTR (where NTR is neurotrophin receptor) can mediate many distinct cellular functions, including cell survival and apoptosis, axonal growth and cell proliferation, depending on the cellular context.
The SWI/SNF (SWItch/sucrose nonfermentable) complex is an ATP-dependent chromatin remodeling complex that has been shown to modulate gene expression and mediate many important cellular processes, including cell cycle, growth and differentiation, DNA repair, and cell adhesion 3– 12.
p75NTR is induced in CNS neurons after many types of injury (Kokaia et al., 1998; Roux et al., 1999; Casha et al., 2001; Ramos et al., 2007), and can mediate many different cellular responses, including neuronal apoptosis or survival, and regulation of axonal growth (Rabizadeh et al., 1993; Frade et al., 1996; Maggirwar et al., 1998; Friedman, 2000).
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