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Interferons (IFN) are multi-functional proteins that induce a large number of genes which mediate many biological processes including host defense, cell growth control, signaling, and metabolism.
NF-κB is an important transcription factor linked to many signal pathways, activating the expression of various molecules that mediate many biological events including cell survival.
Electrostatic forces mediate many biological interactions [43], [44], [45] and have been reported to affect the folding and stability of PrP [46].
Overall, it clearly showed that these cancer-related miRNAs may mediate many biological functions and pathways by regulating the target genes predicted by our integrative and computational method.
Calcium ion channels mediate many biological processes potentially relevant to the malignant process including metastasis (Patton et al, 2003; Huang et al, 2004).
However, as for DOK1, LIM proteins mediate many biological processes acting as a docking site for the assembly of multiprotein complexes (Kadrmas and Beckerle, 2004; Zheng and Zhao, 2007).
Similar(54)
Nitric oxide (NO) is a short-lived free radical that mediates many biological processes.
Calcium is an important intracellular messenger that mediates many biological processes that are relevant to the malignant process.
Soil microorganisms mediate many important biological processes for sustainable agriculture.
Glycoproteins mediate many important biological processes by their involvement in cell adhesion, cell differentiation, cell growth, and immunity [ 22, 23].
Unlike traditional target drug design, which focuses on the inhibition or activation of a single target protein, usually a receptor or enzyme, PPI-based drug design involves inhibition of PPIs interface that mediate many important biological processes by small molecule; it is a novel and creative approach to drug discovery, especially for anti-cancer.
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