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Structural similarities and the highly conserved Erh1 interaction interface from S. pombe to human suggest that ERH family members may all contain a structurally conserved scaffold for connecting with species-specific proteins to mediate diverse cellular functions.
FoxO proteins mediate diverse cellular responses to stress.
Signaling receptors are known to mediate diverse cellular responses such as migration, proliferation and differentiation.
These kinases have different downstream targets and mediate diverse cellular responses, including regulation of apoptosis, proliferation, and inflammation [ 33].
Proteoglycans mediate diverse cellular processes through interaction with a variety of cytokines and protein ligands and there are many cell factors in themselves too.
Activated NF-κB enters the nucleus to induce transcription of a myriad of genes that mediate diverse cellular processes such as immunity, inflammation, proliferation, apoptosis, and cellular senescence [ 166].
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BNIP family proteins possess a conserved BCH domain, which likely mediates diverse cellular functions.
However, recent evidence suggests that the JAK/STAT pathway also mediates diverse cellular responses to various forms of biological stress including hypoxia/reperfusion, endotoxin, ultraviolet light, and hyperosmolarity.
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in mediating diverse cellular processes including cell growth, proliferation, survival and migration (6).
Through interactions with several integrins or CD44, OPN mediates diverse cellular functions such as adhesion, migration, and survival of several different cell types, including regulating and propagating inflammatory responses of macrophages, T cells, and DC [ 11].
Receptor protein tyrosine kinases (RPTKs) are important regulators of intracellular signaling pathways mediating diverse cellular and developmental processes and their dysregulation are closely related with the development of cancer [ 6, 7].
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