Riboswitches and ribozymes are widespread in nature, and mediate important cellular functions such as replication, RNA processing, and protein synthesis.
However, this domain is known to mediate important cellular events such as proliferation, and both resistance and sensitivity to apoptosis during tumourigenesis [ 39, 40].
The microtubule network mediates important cellular processes during interphase, which include cellular migration and intracellular transport.
CNT-induced oxidative stress mediates important cellular processes including inflammation, cell injury, apoptosis, and activation of cellular signaling pathways such as MAPK and NF- κB which are implicated in the pathogenesis of lung fibrosis [ 31, 117].
Syk is a nonreceptor cytoplasmic tyrosine kinase and plays a key role in mediating important cellular activities such as cell adhesion, innate immune recognition, osteoclast maturation, platelet activation, and vascular development.
In addition, growth factors, cytokines and chemokines mediate numerous important cellular functions.
The SWI/SNF (SWItch/sucrose nonfermentable) complex is an ATP-dependent chromatin remodeling complex that has been shown to modulate gene expression and mediate many important cellular processes, including cell cycle, growth and differentiation, DNA repair, and cell adhesion 3– 12.
Although calmodulin is also a family of Ca2+ binding proteins and mediates many important cellular processes [ 27], CALM2 (calmodulin 2) gene was downregulated.
In conclusion, our data are the first to document that EZH2 expression could serve as a potential prognostic marker for NPC, and its overexpression mediates several important cellular processes, all resulting in promoting survival (see Figure 6d).
We selected the putative AGC substrate sequences, since AGC kinase are known to mediate diverse and important cellular functions in mammalian cells.
Neutrophils, macrophages, and other inflammatory cells mediate a number of important cellular functions in injured tissue [33], [34].
