Sentence examples for mediate cytotoxic effects from inspiring English sources

Both HB22.7 and rituximab activate the p38 signaling pathway, and it has been hypothesized that p38 activation may mediate cytotoxic effects.

Antigen-bound IgG does also mediate cytotoxic effects through interaction with FcγR present on effector cells, such as macrophages, neutrophils or NK cells 28.

CCl4 is metabolized by hepatocytes, giving rise to toxic trichloromethyl (CCl3) radicals, which mediate cytotoxic effects and eventually lead to massive centrilobular liver necrosis [ 43].

In the Her2 positive SKBR-3 cells, mechanisms other than HSP inhibition appear to be utilized to a greater extent by the F. leucopyrus decoction to mediate cytotoxic effects.

In our efforts to identify PPD-specific cytotoxic mechanisms in lipid rafts, we demonstrated that accumulated intracellular ceramides mediate cytotoxic effects of PPD, leading to growth inhibition and apoptosis in distinct cancer cells.

Among the biological activities of tumor protein p53 (p53), induction of apoptosis has a prominent role in tumor suppression by eliminating incipient cancer cells and in mediating cytotoxic effects that in part determine the success of conventional cancer treatments.

Modulation of HSP 90 and HSP 70 expressions is a possible mechanism by which the decoction of F. leucopyrus mediates cytotoxic effects MCF-7 and MDA-MB-231 cells.

By using a tumor-specific cell internalization moiety (N6L) and/or an anti-cancer drug (DOX) on the MNP surface, we aim at enhancing the intracellular MNP uptake as well as mediating cytotoxic effects beyond hyperthermia, to reach tumor cells that escape the heat treatment.

Therefore, cancer cells lines resistant to the ascorbic acid mediated cytotoxic effect should also be more resistant to the toxic effect of hydrogen peroxide than ascorbic acid susceptible cell lines.

Compared to other cancer cell lines, the level of catalase protein was significantly higher in BT-20 cells highly resistant to the ascorbic acid mediated cytotoxic effect compared to the other cancer cell lines.

In contrast, the glioblastoma cell lines U-251 and U-87, extremely susceptible to the ascorbic acid mediated cytotoxic effect (EC50 < 5.0 mmol/L), were most sensitive to hydrogen peroxide, too (Table 2).