Sentence examples for mediate oncogenic effects from inspiring English sources

Mutations mediate oncogenic effects by altering downstream signaling and anti-apoptotic mechanisms [1, 7].

These mutations are postulated to mediate oncogenic effects by altering downstream signaling and anti-apoptotic mechanisms [ 13- 15].

These mutations on the EGFR gene mediate oncogenic effects by altering downstream signaling and antiapoptotic mechanisms, and such oncogenic effects can be inhibited by currently marketed EGFR inhibitors (e.g. gefitinib, erlotinib, and icotinib), which are together termed as the first-generation EGFR inhibitors.

Although ARTN is an estrogen-regulated gene we have demonstrated that it also mediates oncogenic effects in ER-MC including cell invasion and metastasis.

Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk.

By inhibiting cell growth, it has a tumor suppressor function at early tumor stages, whereas at later stages it mediates oncogenic effects (Heldin and Moustakas, 2012; McCleary-Wheeler et al., 2012; Truty and Urrutia, 2007).

It is tempting to speculate that both oncogenic pathways converge upon the initiation of translation to mediate their oncogenic effects.

It has been previously reported that ARTN activates AKT to mediate its oncogenic effects in endometrial carcinoma cells [ 9].

The oncogenic Src protein kinase itself is overexpressed in a large number of tumor types and interacts with multiple tyrosine kinase receptors, including EGFR and HER2 [ 41] to mediate its oncogenic effects of promoting growth and metastasis.

Our findings suggested that Yes-associated protein contributes to primary liver tumorigenesis and likely mediates its oncogenic effects through modulating Survivin expression.

Therefore identification of transcriptional targets mediating the oncogenic effects of the EGFR-MEK-ERK pathway would be highly relevant.