Sentence examples for mediate adverse effects from inspiring English sources
Our findings suggest that expanded polyglutamine proteins mediate adverse effects through activation of p38MAPK signaling and that this cytotoxicity is antagonized by PKCι, which enhances protective signaling through the ERK pathway.
Our data do not allow us to formally exclude a role for JNK, and it is conceivable that the concerted action of both these pathways mediate adverse effects on polyglutamine expressing cells.
Whether MPs mediate adverse effects of blood transfusion in the critically ill remains to be determined.
A multi-component therapeutic can be envisaged that leverages systems biology to amplify glucocorticoid activity selectively in the network context of inflammatory cells over alternative cellular networks that mediate adverse effects.
These data support a selective activity profile for this combination, in which dipyridamole amplifies the desired anti-inflammatory activity of prednisolone in immune cells without enhancing glucocorticoid action in alternative cellular networks that mediate adverse effects to generate an improved therapeutic index.
Indeed, Thr within CLS1 is a critical molecular recognition or docking site for PINK1; this site also signals Fbxo3 recruitment leading to CLS1 poly-ubiquitination at K. Fbxo15 alone is sufficient to significantly impair mitochondrial oxygen utilization and lung stability, whereas PINK1 is required to mediate adverse effects of S. aureus on pulmonary injury.
Adipokines dysregulation has been considered as one of the major mechanisms mediating adverse effects of excess body fat on metabolic abnormalities.
ERα mediates adverse effects of estrogen on the prostate, including aberrant proliferation, inflammation, and malignancy (Ellem and Risbridger 2009).
FAT/CD36 is a fatty-acid transporter also known as scavenger receptor, which mediates adverse effects of saturated FFA.
It is hypothesized that PGH synthase mediates adverse effects of DES and other carcinogenic estrogens such as induction of neoplastic transformation and genotoxicity.
We reviewed differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories to identify hazards and molecular mechanisms mediating adverse effects.
