Sentence examples for mechanistic changes that from inspiring English sources

Differential interactions imply mechanistic changes that are a result of an organism's response to environmental conditions [ 16].

The early effects of the classic rodent non-genotoxic hepatocarcinogen phenobarbital have been investigated in the Fisher rat using a combination of metabolomics and transcriptomics, to investige early stage mechanistic changes that are predictive of longer term pathology.

Multiple studies have attempted to decipher molecular mechanisms crucial for induction of anesthesia (reviewed in [ 9- 12]), yet only rare reports characterize mechanistic changes that occur upon emergence from anesthesia [ 13- 16].

More work is underway to efficiently process the wealth of biclusters extracted for a more informed interpretation of the mechanistic changes that take place during the formation of hepatotoxicity.

This review discusses the mechanistic changes that occur during the development of HCC and the potential targets that are being investigated for new screening techniques, with the hope that this will lead to a more personalized treatment regimen to improve patient outcome.

The decomposition of biomass to biocoal is a very complex chemical process, yet detailed understanding of the mechanistic changes that occur can allow for system control and optimization.

The only mechanistic change that generates P-clusters is an increase in the redox environment (to either DTN or IDS) of the [Fe4S4] clusters.

In particular, our data provide structural and mechanistic insights into changes that accompany gatekeeper substitutions leading to kinase activation and their ability to be targeted by some but not all FGFR inhibitors.

In addition, it is likely that ALT levels elevate well after the mechanistic changes have occurred that led to the liver injury from toxic exposure.

As an approach to achieving this goal, mechanistic interpretations based upon gene expression changes that are determinants of adverse toxicological outcomes were applied to the analysis of low-dose gene expression profiles.

Our study was conducted to identify natural product-induced gene regulation and/or expression changes that may identify mechanistic pathways helping to elucidate biochemical, cellular, or metabolic FS targets.