Sentence examples for mechanistic data that from inspiring English sources

We focus on several key aspects in prebiotic research in relation to MetS and provide mechanistic data that support the use of prebiotic fibers in order to alter the gut microbiota composition and SCFA profiles.

Cell lines can be utilized for the generation of mechanistic data that could potentially be used for toxicity assessments.

Instead, they are likely to provide important safety and mechanistic data that underpin definitive studies in patients treated with curative intent.

Additionally, such findings using an in vivo model system may provide key mechanistic data that can further strengthen current epidemiologic association studies.

Our studies are important in that complex and validated ovine models may, to some extent, be comparable to other animal models such as swine that can generate robust mechanistic data that lend themselves to translational research.

This review aims to outline the clinical data with serelaxin in patients with AHF, integrating and extrapolating the available mechanistic data that could help to explain both the short- and long-term clinical effects observed with this novel agent.

Importantly, by combining various assays, it is possible to derive mechanistic toxicity data that complement descriptive toxicity assessments while also achieving replacement of animal testing.

"The most appropriate and scientifically based evaluation of the cancers reported in humans and laboratory animals as well as supportive mechanistic data is that glyphosate is a probable human carcinogen," the report states.

We also provide mechanistic data demonstrating that CRMP4 regulates spindle microtubules consistent with its known role in the regulation of the microtubule cytoskeleton.

The key findings in this study are the identification of an antimicrobial activity of PrP together with the characterization of epitopes mediating this effect, as well as mechanistic data showing that the antimicrobial activity is mediated by bacterial membrane permeabilisation.

This is supported by our mechanistic data showing that treatment with the full (active) cholera toxin protein increases immunostaining for the Tie2 receptor and induces the nuclear localization of the transcription factor Hes3, two processes characteristic of self renewing NSCs [22], [23], [24], [25].