Sentence examples for mechanical force threshold from inspiring English sources

The lower mechanical force threshold of IgG-BCR activation is dependent on its cytoplasmic tail.

Mechanistically, we found that the cytoplasmic tail of the IgG-BCR heavy chain is both required and sufficient to account for the low mechanical force threshold.

All of these results suggested that the lower mechanical force threshold of memory IgG-BCR activation depends on its cytoplasmic tail.

All these data drive us to speculate that the breakthrough of the high-end but not the medium-level or low-end mechanical force threshold might be contributed by myosin IIA.

However, it was clear that the high-end (56 pN) and medium-level (43 pN) but not low-end (12 pN) mechanical force threshold was more influenced by the inactivation of integrin, suggesting that the breakthroughs of the medium-level and high-end threshold of mechanical forces are partially supported by the inside-out activation of integrin.

The unexpected extremely low mechanical force threshold (might be less than 12 pN or even lower) for the memory IgG-BCR but not the naive IgM-BCR activation drove us to ask the next question: why does the memory IgG-BCR behave differently from the naive IgM-BCR?

Specifically, an increase of the mechanical force from one threshold to another threshold dramatically enhanced the activation of the naive IgM-BCRs.

These results defined the mechanical force sensitivity and threshold that are required to activate different isotyped BCRs.

As a system control, it was clear that the activation of the naive B1-8-IgM-BCRs expressed in Ramos B cells was also dependent on mechanical force with a multi-threshold effect.

The force threshold for mechanical perforation in the porcine heart was found to be lower for right- compared with left-sided chambers, and also lower through recently created RF lesions compared with nonablated tissue.

In conclusion, all these results define the sensitivity and threshold for mechanical force that is required to activate IgM-BCRs and isotype-switched IgG-BCR and IgE-BCR, highlighting the significant contribution of mechanical force signals in the enhanced activation of isotype-switched IgG-BCR and IgE-BCR expressing memory B cells in rapid and high-titered antigen recall responses.