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Six groups of dogs from two facilities (total n=46) were observed in the home pen and tested for mechanical pressure threshold.
In this study, we examine the effect of modern and traditional home pen design, overall facility design, husbandry, history of regulated procedures, strain and sex on welfare-indicating behaviours and mechanical pressure threshold.
Mechanical Pressure Threshold (MPT): Lowered mechanical pain threshold has been previously reported in DOMS models suggesting sensitization of muscle nociceptors in response to mediators of the inflammatory process [ 6, 40].Tenderness in paraspinal muscle tissue was assessed using a hand-held dynamometer (Microfet 2, Hoggan Health Industries , Inc West Jordan, UT).
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Our findings showed more positive welfare indicating behaviours in dogs with higher mechanical pressure thresholds.
Meta-analysis was appropriate for studies examining the immediate effect of SMT on mechanical pressure pain threshold (PPT).
The administration of intrathecal nicotinic acetylcholine receptor agonists reduced mechanical paw pressure thresholds with a potency of epibatidine = A-85380 >> nicotine > choline in the normal rat.
Experimental measures of pain sensitivity (mechanical pressure pain detection threshold) and central pain excitability (phasic heat temporal summation and heat aftersensations) were assessed before and after TENS.
Intraplantar injection of the chemokine CXCL2/3 (macrophage inflammatory protein-2) induced selective neutrophil recruitment without overt signs of inflammation or changes in mechanical nociceptive thresholds (paw pressure threshold).
To study the analgesic potency of the α2 agonist romifidine in the horse using both an electrical current and a mechanical pressure model for nociceptive threshold testing.
Paw withdrawal threshold (i.e. the pain threshold) to mechanical pressure was determined by the Randall-Selitto method (Analgesy-Meter, Ugo Basile, Comerio, VA, Italy) 24 h after surgery.
Such compounds have been tested in vivo by measuring the paw withdrawal threshold to mechanical pressure after complete Freund's adjuvant injection.
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