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In subgroup analysis, the change in the mean wrinkle depth was significantly lower in the AVGP group than in the control group.
The changes in the maximal width of the largest wrinkle and mean wrinkle depth from the baseline value after 4 weeks and 8 weeks of treatment are shown in Table 4.
On the other hand, we demonstrate that daily oral AVGP (40 μg of Aloe sterols) significantly reduced facial wrinkles in women aged ≥40 years in terms of the mean wrinkle depth.
Furthermore, the percent change in the mean wrinkle depth was significantly lower in the AVGP group than in the placebo group at 8 weeks in this age group (P=0.035).
In the placebo group, the percent change in the maximal width of the largest wrinkle and mean wrinkle depth from baseline increased at 8 weeks (3.96%±4.23% and 0.73%±0.96%, respectively), whereas the values were lower at 8 weeks compared with those at baseline in the AVGP group (−2.18%±4.09%and−0.11%±1.0%0%±4.09%and−0.11%±1.0%
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Our results show that bee-venom serum treatment clinically improved facial wrinkles by decreasing total wrinkle area, total wrinkle count, and average wrinkle depth.
In this research, we found that bee-venom serum treatment clinically improved facial wrinkles by decreasing total wrinkle area, total wrinkle count, and average wrinkle depth.
Bee-venom serum provided greater efficacy in terms of total wrinkle area, total wrinkle count, and average wrinkle depth in subjects with photodamaged skin.
The image analysis using replicas was performed at week 12, when significant differences in total wrinkle area, total wrinkle count, and average wrinkle depth were observed.
Table 2 shows the average values for R y (wrinkle depth) and R a (average skin roughness) over time.
By defining an area within the image and tracing a segment of known length in a defined position across the wrinkle and perpendicular to it, it was possible to calculate the profilometric roughness parameters: average roughness of the analyzed profile; total wrinkle height; and maximum wrinkle depth.
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