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In addition, instrumental evaluation by digital skin profilometry of the treated areas revealed a 41% reduction in average wrinkle depth (7.29 ± 1.04 × 10−2 mm pretreatment vs. 4.31 ± 1.16 × 10−2 mm at 90 days posttreatment; p < 0.001), improved skin texture, more homogeneous and uniform skin color, and declined facial hemoglobin and melanin concentrations.
Bee-venom serum provided greater efficacy in terms of total wrinkle area, total wrinkle count, and average wrinkle depth in subjects with photodamaged skin.
In this research, we found that bee-venom serum treatment clinically improved facial wrinkles by decreasing total wrinkle area, total wrinkle count, and average wrinkle depth.
Our results show that bee-venom serum treatment clinically improved facial wrinkles by decreasing total wrinkle area, total wrinkle count, and average wrinkle depth.
The image analysis using replicas was performed at week 12, when significant differences in total wrinkle area, total wrinkle count, and average wrinkle depth were observed.
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The changes in the maximal width of the largest wrinkle and mean wrinkle depth from the baseline value after 4 weeks and 8 weeks of treatment are shown in Table 4.
On the other hand, we demonstrate that daily oral AVGP (40 μg of Aloe sterols) significantly reduced facial wrinkles in women aged ≥40 years in terms of the mean wrinkle depth.
In subgroup analysis, the change in the mean wrinkle depth was significantly lower in the AVGP group than in the control group.
In the placebo group, the percent change in the maximal width of the largest wrinkle and mean wrinkle depth from baseline increased at 8 weeks (3.96%±4.23% and 0.73%±0.96%, respectively), whereas the values were lower at 8 weeks compared with those at baseline in the AVGP group (−2.18%±4.09%and−0.11%±1.0%0%±4.09%and−0.11%±1.0%
Table 2 shows the average values for R y (wrinkle depth) and R a (average skin roughness) over time.
By defining an area within the image and tracing a segment of known length in a defined position across the wrinkle and perpendicular to it, it was possible to calculate the profilometric roughness parameters: average roughness of the analyzed profile; total wrinkle height; and maximum wrinkle depth.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com