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More recently it has been suggested that Tks5 may undergo alternative splicing to remove the first SH3 domain [42], however the relationship between this putative alternatively spliced Tks5 and Tks4 are not clear.

Moreover, BT may undergo alternative routes other than paracellular passage across the epithelium.

It is estimated that 94% of genes may undergo alternative splicing in humans [ 31].

However, macrophages in tumor microenvironment may undergo alternative activation and change into tumor promoters called tumor associated macrophages (TAM).

As a result, APP may undergo alternative proteolytic processing, leading to the accumulation of its C-terminal peptides within neurons.

The RNA levels between the normal and IPF lung tissue remains non-significant, which suggests that plakoglobin may undergo alternative splicing and/or other post-translational modifications.

Similar(54)

Although further studies may reveal more genes undergo alternative splicing, we believe this can not affect our results.

Though alternative splicing is known to be universal in eukaryotes, we may underestimate the number of genes that undergo alternative splicing.

It has been estimated that about three-quarters of all human genes undergo alternative splicing [ 20- 22], which may affect the function, localization, binding properties, and stability of the expressed proteins [ 23].

Bioinformatics analyses predict that the majority of human genes undergo alternative splicing, generating proteins – many of which may have regulatory functions.

In addition, noncanonical poly(A) sites appear to be more frequent in genes that undergo alternative cleavage and polyadenylation (Tian et al, 2005 and this study) suggesting that they may have a critical role in this process.

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