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With further genetic engineering these mutants may activate alternative hexoses as GDP-sugars for transfer to aglycones in vivo.
Other mutations, such as Asp→Val, may activate alternative signal transduction pathways [ 75].
TGR-β and EGFR may activate alternative splicing of CD44 through p38 MAP kinase.
Pan-caspase inhibition, rather than specific inhibition of Caspase-3/-7, malsolso be an interesting strategy, as it may activate alternative forms of cell death, such as necroptosis.
However, it has been shown that loss of methylation of certain type (e.g., CG) may activate alternative back-up cellular systems, which in turn may catalyze hypermethylation of other types of methylation (e.g., CHH) and produce aberrant methylation patterns [ 30].
Similar(54)
The subsequent increase in prorenin and renin may activate several alternative pathways.
It has been speculated that accumulation of ICs involving GPI may activate the alternative complement pathway to cause inflammatory arthritis [ 16].
Threonine phosphorylation on Syk by PLK1 has been reported to be a part of an antiapoptotic mechanism, and the disruption of the mechanism may have activated alternative PLK1-dependent phosphorylation events.
Interestingly, several pro-proliferative pathways were up-regulated, which may represent attempts of masitinib treated cells to activate alternative pro-proliferative pathways.
Experimentally, it is becoming apparent that treatment of breast cancer cells with endocrine therapies can rapidly activate alternative signal transduction pathways, which may limit the initial anti-tumour response, allow resistance to develop and, ultimately, encourage invasive behaviour [ 75].
However, for samples where the density of dislocation sources has been reduced significantly by annealing, an additional strengthening mechanism, so-called dislocation source-limited hardening, may operate as a higher stress is required to activate alternative dislocation sources.
More suggestions(15)
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may activate necrotic
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may activate CaMKIα
may seek alternative
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