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Increase in intracellular calcium concentrations may trigger apoptotic pathways or even amplify other apoptotic stimuli.
TNFR1 may trigger apoptotic and anti-inflammatory signals through Fas-associated death domain (FADD) and activation of the caspase cascade.
These findings suggest that the drug may trigger apoptotic death of PC cells, at least in part by interfering with cytoskeletal integrity.
The increase of free Ca2+ in the outer hair cells [ 96] or the activation of Ca2+ and calmodulin-controlled calcineurin [ 97] may trigger apoptotic or necrotic cell death pathway without ROS production.
For example, different experimental models of pancreatic injury produce different percentages of β-cell ablation, may trigger apoptotic or necrotic cell death, and may or may not be accompanied by inflammatory responses.
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Activation of this proapoptotic protein may potentially trigger apoptotic cell death and is a possible explanation of why CR hastened the clinical onset of disease and disease progression in G93A mice Conversely, there were no significant differences in the protein content of caspase 9, cleaved caspase 9 or the ratio of cleaved caspase 9/caspase 9/caspase
These DSBs may then trigger apoptotic cell death in glioblastoma multiforme (GBM).
Disulfiram/copper may trigger intrinsic apoptotic pathway via modulation of the Bcl2 family.
Nonhemodynamic-dependent mechanisms of injury during sepsis, inflammatory and immunologic, may trigger this apoptotic response.
It is possible that MMR recognition of DNA damage may trigger an apoptotic pathway or that futile cycles of DNA damage/repair mediated by the mismatch repair machinery generate lethal DNA strand breaks [ 196].
We also show that Sorafenib may trigger non-apoptotic cell death in regenerating livers by features resembling mitotic catastrophe.
Related(20)
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