Sentence examples for may reprogram epigenetic from inspiring English sources

This raises the hypothesis that the normal tissues of wild-type embryos may reprogram epigenetic instability or epigenetic remnants of the original somatic cells.

Differential expression of regulating enzymes may affect epigenetic reprogramming events in different samples (59).

For example, in utero exposure to certain so-called epigenetic diets that affect key tumor-related gene expression through epigenetic regulation may lead to reprogramming of primary epigenetic profiles of the fetal genome, resulting in different susceptibility to diseases, including cancer (Li et al. 2014).

Vector design is an important consideration for effective genetic correction of cells prior to reprogramming as epigenetic modifications during this process may lead to irreversible silencing.

Cell cycle arrest promoted by p21 may inhibit epigenetic modifications required for reprogramming, as those modifications occur more readily in proliferating cells.

The rapid and sustained activation of endogenous genes in their native chromatin context by this approach may facilitate reprogramming with transient methods that avoid genomic integration and provides a new strategy for overcoming epigenetic barriers to cell fate specification.

Factors in oocytes or early cleavage embryos presumably contribute to both rapid telomere reprogramming and epigenetic reprogramming during early embryo development.

These observations suggest that the strength of reprogramming targeting epigenetic barriers is important for successful reprogramming.