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In such cases "the environment may induce epigenetic variation by directly affecting the germline or by affecting germ cells through the mediation of the soma, but, in either case, subsequent transmission is through the germline" (Jablonka and Raz 2009, 133).
First, ART may induce epigenetic defects in the conceptus by modifying the embryo environment.
Parental conditions before, during and after conception (periconception period) may induce epigenetic changes in gametes and embryos [ 8 ].
13 More subtle changes in maternal nutrition that need not affect birth size may induce epigenetic changes in the offspring.
In addition, we show for the first time that etoposide may induce epigenetic instability in the form of altered DNA methylation patterns in eukaryotes.
More recently, increasing evidence indicates that alcohol may induce epigenetic alterations, in particular aberrant DNA methylation patterns, which also could be important contributory factors to alcohol-induced carcinogenesis.
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Therefore, in addition to allow an initial burst of IFN-γ following appropriate B cell antigenic activation, IFN-α may possibly induce epigenetic modifications in the IFN-γ gene that increase responsiveness to IL-12 (Fig. 3D).
Previous studies have demonstrated that BrdU incorporation could affect DNA structure, and may thus induce epigenetic changes necessary for the reprogramming.
Apart from that, these factors may contribute to induce epigenetic modifications during SE.
These studies suggest that the same stressor may induce different epigenetic modifications in different brain regions, even when acting on the same genes.
This indicates that cigarette smoke metabolites may induce transgenerational epigenetic inheritance of vulnerability for DNA integrity defects through the paternal germ line.
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