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Thus, a high-resolution analysis of the ligands bound to human CD1d is critical for identifying compounds of interest that may regulate human NKT cell responses.

Finally, the clinical report of the development of ulcerative colitis during CTLA4-Ig (abatacept) therapy in a patient with RA reinforces our hypothesis that costimulatory molecules may regulate human Th17 development [18].

We propose that E4BP4/ NFIL3 may regulate human APP expression via binding to distal regulatory sequences.

Our studies in a human model of aberrant T-lymphocyte homeostasis wherein IL-15 and, to a lesser extent, IL-7 levels inversely correlate with circulating T-lymphocyte levels provide evidence that IL-15 and IL-7 may regulate human T-lymphocyte homeostasis.

Furthermore, we present the novel discovery that NANOS3 localizes to the nuclei of human germ cells and may regulate human germ cell development at both mRNA and DNA levels in contrast to the exclusive regulation at the mRNA level that has been previously reported (32, 59– 61).

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Piwil1 is also detected in human CD34+ cells but not in well-differentiated cells, suggesting it may determine or regulate human stem cell development [ 32].

In this respect, one emerging possibility is that MTT may be represented in the sensory-motor systems that regulate human movement (i.e., MTT is embodied) [20] [22].

Despite these important discoveries, additional alleles that may regulate aging in humans and allow a minority of the population to attain extreme old age have likely yet to be identified.

Bioinformatics and cloning studies have estimated that miRNAs may regulate 30% of all human genes [3][4].

These studies support CRH's role in labor initiation, particularly its function as a placental clock that may regulate the length of human gestation [ 64].

Although initial rodent studies have produced discrepancies as to whether pro-inflammatory cytokines may regulate resistin, several recent human studies have supported the concept of inflammatory cytokine mediation of resistin [ 17, 18].

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