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This suggests that Rdx may regulate nuclear import of Ci.
While it is unclear that the molecular causes of HGPS overlap with those of normal aging, it has been reported that A-type nuclear lamins, encoded by LMNA and juxtaposed to the nuclear envelope, may regulate nuclear pore function.
Considering the observations that the nuclear anchoring was observed in many other embryonic and postembryonic divisions and that DSH-2/Dishevelled is localized to the posterior cortex where the nuclei are anchored in the T.p and V5.p cells as in the EMS cell (Walston et al. 2004; Mizumoto & Sawa 2007a), Wnts may regulate nuclear anchoring throughout the C. elegans development.
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Subsequently, confocal and western blot analyses show that nNOS/Nox4 translocates to the nucleus, suggesting that nNOS/Nox4 may directly regulate nuclear signaling.
The COOH terminal of LYRIC (amino acid 546 582) is the predominant regulator of nuclear localization [ 40], and its phosphorylation may regulate LYRIC nuclear localization.
As the expression of TAF8 may regulate the nuclear localization of other TAFs and/or TFTC subunits, as well as specific cell differentiation processes, the SMAT complex may be an important regulator of the composition of different TFIID or TFTC-type complexes in the nucleus and/or cell differentiation processes.
Previously, we have shown that SF2/ASF binds directly to cytoplasmic mRNA in vivo and enhances the translation of reporter mRNAs both in vitro and in vivo [8], suggesting that SF2/ASF may regulate the nuclear and cytoplasmic fate of specific endogenous mRNAs.
We speculated that bam may regulate Set2 nuclear localization.
The mechanisms by which Akt may regulate AIF nuclear translocation are not clear.
However, Lee et al. (2011) have suggested a protective effect in which increases in p38 activity may regulate Xbp1 nuclear translocation and activity, and thus may represent a compensatory mechanism to maintain homeostatic response.
Consistent with our recent study suggesting that GSK-3 may regulate the nuclear activity of NF- κB in leukaemia cells by affecting the binding of p65/p50 to the promoters of NF- κB target genes Bcl-2 and XIAP (Ougolkov et al, 2007), we found that GSK-3 positively regulates NF- κB p65 binding to Bcl-2 and XIAP promoters in human renal cancer cells.
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