Sentence examples for may modulate synaptic from inspiring English sources

Together, these results suggest that GluR6 Q/R site RNA editing may modulate synaptic plasticity and seizure vulnerability.

Thus, dopaminergic afferents to the NAc may modulate synaptic transmission either by releasing dopamine (DA) directly onto synapses or by causing a more diffuse increase in extracellular DA levels (Garris et al, 1994; Grace, 1991; Descarries et al, 1996).

Secreted semaphorins play critical roles in growth cone guidance, axonal positioning and in modulating apical cortical dendrites [37] [39], dendritic branching and spine maturation [39] and may modulate synaptic transmission in the adult brain [40].

Induction of LTP and LTD in the CA1 region of the hippocampus involves numerous protein kinases and/or phosphatases [13], [18], which are believed to be critical for the translation of electrical activity into persistent subcellular alterations that may modulate synaptic strength.

The different putative sites of in- and outputs to peptidergic neurons in the VNC are summarized in Table 3. Peptides released from varicosities of leucokinin, CCAP, HUG-, EH and corazonin neurites along the DM tract may modulate synaptic transmission around the DM tracts, or might represent direct input signals to peptidergic neurons.

Alternatively, physiological levels of systemic insulin may modulate synaptic plasticity in vivo by promoting the phosphorylation of IRS2 within neurons that are receptive to LTP.

These results suggest that DA may modulate inhibitory synaptic transmission in CeA through D(1) receptor activation primarily by a presynaptic mechanism.

ANO1 (TMEM16A) is a calcium-gated chloride channel in secretory epithelia and retina [17] [20], while ANO2 (TMEM16B) is a candidate calcium-gated chloride channel in photoreceptor neurons and olfactory sensory neurons [21].n photoreceptor neurons, ANO2 may modulate pre-synaptic release of glutamate neurotransmitter to second order neurons [22].

The D2 receptor antagonist eticlopride was effective in blocking the suppression of synaptic responses induced by food-related cues and by chocolate, but other neuromodulatory transmitters that modulate synaptic responses in the entorhinal cortex may be active during anticipation and consumption of food reward [ 30, 38- 41].

Mutants show a reduction in excitatory neurosecretion, and mth appears to modulate synaptic strength in neurons by regulating vesicle trafficking [20]; this may be important in sensorimotor ability, as mth mutants also show enhanced visuomotor synchronization and phototaxis [21].

Given that IRS proteins are not tethered to the plasma membrane, the recruitment of these molecules to IRS2 may serve the critical function of relocalizing activated signaling pathways to a site within the neuron where they can modulate synaptic plasticity.