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SCFA may modulate insulin sensitivity by reducing fatty acid flux.

Interestingly, ERβ also may modulate insulin secretion, perhaps in the acute situation.

These adipokines may modulate insulin sensitivity and function in a pro- or anti-inflammation capacity in metabolic dysfunction [ 1, 2].

Moreover, CD14KO mice were hypersensitive to insulin even when they were fed a normal diet, suggesting that CD14 may modulate insulin sensitivity in physiological conditions.

Moreover, LPS receptor Cd14-/ mice tend to be resistant to this chronic inflammatory state and were hypersensitive to insulin even when they were fed a normal diet, suggesting that CD14 may modulate insulin sensitivity in physiological conditions [ 57].

One of the significantly enriched KEGG pathway terms for the target genes of the cattle-specific miRNAs is the insulin signalling pathway, raising the possibility that some of these miRNAs may modulate insulin resistance in ruminants.

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Also, it should be kept in mind that the compensatory insulin response includes both changes in insulin secretion as well as adaptations in hepatic insulin extraction (24) and changes in incretin hormone responses that may modulate both insulin secretion and hepatic insulin extraction (25).

We performed an affinity purification of O-GlcNAc-modified proteins and observed that a high percentage of these proteins are regulated by insulin signaling and/or impact insulin pathway functional outcomes, suggesting that the O-GlcNAc modification may control downstream effectors to modulate insulin pathway mediated cellular processes.

Leptin has been shown to be able to modulate insulin secretion.

Along with FFAs, they modulate insulin sensitivity by altering the phosphorylation state of insulin receptor substrates.

Drugs that target pancreatic KATP channels are used to modulate insulin secretion.

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