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Epigenetic changes refer to heritable changes that may modulate gene expression without affecting DNA sequence.
Further P. falciparum may modulate gene expression in bystander erythroblasts and thus influence pathways of erythrocyte development.
Since cells return to cycle normally only after 24 h, such protein-protein interactions may modulate gene expression specifically in "white" medium.
While RNA molecules in the sperm chromatin may modulate gene expression in the progeny [21], paternal inheritance of epigenetic information in the form of CpG methylation patterns that in turn direct the establishment of site-specific non-CpG methylation may be but one more example in this class of non-Mendelian heredity.
As well as miRNAs may modulate gene expression, the opposite may also be true.
The profibrotic and hypoxic environment associated with SSc may modulate gene expression profiles of circulating monocytes.
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However, the ability of GTT, an isomer of vitamin E, in inducing apoptosis in cancer cells may not necessarily correlate to its antioxidant characteristics, but GTT may modulate gene-regulatory functions through mechanisms unrelated to their antioxidant properties.
The complexes may modulate genes by either the classical ERE pathway or via protein-protein interactions.
The SERM – ER complex can recruit coactivators and corepressors, and these complexes may modulate genes by different pathways.
Recently, it has been shown that that miRNAs may also modulate gene expression by base-pairing to the CDS region of target mRNAs.
In addition to temperature, a number of factors including ion concentration, nutrient availability, pH, iron level, oxygen tension, osmolarity, and growth phase may also modulate gene expression [10].
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