In particular, regulatory changes involving a limited genetic diversity can affect the expression of alternatively spliced isoforms and may modulate timing, localization, and abundance of gene expression.
That is, changes in cis motifs that modulate localization can have isolated effects independent of other functions of the mRNA.
Levels and subcellular localization of VRK2 may modulate different responses where the assembly of JIP1 complexes is required, since in its presence the level of activation will be lower the higher the level of VRK2 protein is.
Because the AKT signaling may modulate BCRP function through regulating its intracellular localization [203], [208] and post-transcriptionally down-regulating BCRP expression in BCR-ABL+ CML cells [128], these findings suggest there is likely a link between upstream effectors of AKT and BCRP in stem cell populations.
Cytokines at the local site may modulate exudative PMN apoptosis.
When present, however, Podocalyxin's cytoplasmic tail potently recruited NHERF-1 to the apical plasma membrane; in its absence NHERF-1 was dispersed throughout the cell, suggesting that Podocalyxin may modulate NHERF function by regulating its apical membrane localization.
Since it was recently demonstrated that HIV-1 Gag assembly and budding are regulated by the nuclear export mechanism of the Gag-encoding mRNA, it was felt that alterations in the sub-cellular localization and the dynamics of Rev may modulate or affect Gag assembly.
These differences in subcellular localization of both FoxM1 and p27Kip1 in the Igf1−/− mouse cochlea suggested that FoxM1 may modulate the nuclear targeting of p27Kip1.
Therefore, other factors may modulate fracture risk.
Thus, different dispersion protocols may modulate sediment toxicity.
