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Regarding the adult liver-enriched miRNAs, similar to let-7, miR-23b is capable of inhibiting cell proliferation [44], and may mediate cell cycle arrest in mature hepatocytes.

Let-7 family members have been shown to target proliferation-promoting genes, such as HMGA2 [37] and IGF2BP1 [39], and as such, may mediate cell cycle arrest in the adult liver.

Increasing evidence supports that autophagy may mediate cell death in cancer cells which are apoptosis defective or hard to induce.

Serum and glucocorticod kinase is an interesting target kinase of ERK5 [ 175]; it may mediate cell survival influences of ERK5 to cellular stress [ 176].

Although further analysis is needed to identify the underlying mechanism by which ABI3 induces p21 WAF1 expression, our findings indicate that increase in p21 WAF1 may mediate cell cycle arrest and senescence by blocking the CDk/Rb/E2F axis.

As mentioned above, the up-regulation of CCR7 expression was found in NPC CSCs and may mediate cell migration in response to its ligand CCL21 in lymph nodes [36], [71].

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In addition, it is speculated that STIM1 in the plasma membrane may mediate cell-cell interactions through its extracellular facing N-terminal domain [32], [33].

These same molecules may mediate cell-to-cell adhesion and allorecognition in the sponge [ 39, 43, 44].

The ECM protein vitronectin binds CD155 in vitro suggesting that CD155 may mediate cell-substrate adhesion [ 26].

The cadherin repeat domains often exist as tandem repeats in the extracellular regions; they may mediate cell-cell contact when bound to calcium.

A visible increase of Ki67-positive cells was observed (Figure S7), further supporting the idea that cell cycle status of the host cell within these organs may also mediate cell fusion.

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