Sentence examples for may mediate resistance from inspiring English sources

These mechanisms may mediate resistance to the TKIs in breast cancer cell lines.

Thus, Metnase may mediate resistance to Topo IIα inhibitors, and could be a biomarker for clinical sensitivity to anthracyclines.

Since ALDH1A1 gene expression is elevated in TG versus NTG cells, ALDH1 enzymatic activity is disproportionably high in cells with the CoCSC phenotype, and this activity may mediate resistance to CPA, we next asked whether the frequency of ESA+CD44+ALDH+ cells was elevated in UM-C4, UM-C6 and OMP-C8 tumors from mice receiving CPA versus those being administered vehicle.

FGFRs may mediate resistance to imatinib in GIST [ 96, 97].

Increased glutathione (GSH) in MM may mediate resistance to L-PAM.

Homologs of [GenBank: HSM_1736] and [GenBank: HSM_1737] in other bacteria are known to be horizontally transferred and may mediate resistance to antibiotics [ 87].

FGFR signaling may also mediate resistance to chemotherapy in breast cancer.

As the most relevant mechanism of drug resistance developed by these cell lines is the overexpression of ABCB1 (Serra et al, 1993; Hattinger et al, 2009), additional experiments were performed in order to verify whether this membrane transporter may also mediate resistance against these two drugs.

The Hoechst dye low side population (SP) cells are enriched for tumor initiating activity compared to non-side population (NSP) cells and express elevated ABCG2 and other multi-drug resistance transporters that may mediate therapeutic resistance.

Although some animal experiments suggest that glucosamine may mediate insulin resistance, it is not clear whether glucosamine is the mediator of vascular complications associated with hyperglycemia.

Endothelin-1 (ET-1) may mediate increased resistance to hepatic sinusoidal blood flow.