Sentence examples for may facilitate malignant from inspiring English sources

The enzyme may facilitate malignant transformation and render cells more resistant to apoptosis [ 37- 39].

Loss of function of both alleles leads to complete knockdown of these genes, which may facilitate malignant transformation.

It is likely that the combined chronic hepatosteatosis, accelerated poor quality control, and increasing oxidative damage with age may facilitate malignant transformation and tumor formation in the CMA-deficient livers.

Our demonstration that HRBECs from all subjects displayed prosurvival changes after XE exposure does not claim that all exposed persons will develop cancer, only that such exposure can cause changes that may facilitate malignant progression.

Experiments examining the cooperation of c-Myc and knockouts of p19ARF and/or p53 in mouse embryo fibroblast models have suggested that suppression of c-Myc-induced apoptosis may facilitate malignant transformation and tumorigenesis (Zindy et al, 1998).

These results indicate that the rapamycin-regulated eIF4E pathway is crucial in inducing growth arrest, and dysregulation of eIF4E may facilitate the malignant phenotype.

Prolongation of epithelial cell survival is important to facilitate normal protective immune responses, but if sustained could theoretically facilitate malignant transformation.

Several studies demonstrated the presence of chromosome alterations in MSCs derived from MDS or leukemic patients, suggesting that unstable MSCs may facilitate the expansion of malignant cells.

These data therefore suggest that upregulation of IGF-1R due to loss-of-function of p53 may facilitate selection of a malignant population of cells.

Many core circadian proteins are involved in the cell cycle and the DNA damage response (Sahar and Sassone-Corsi, 2009), thus may facilitate the proliferation of transformed malignant cancer cells while normal post-mitotic cells should be exempted from the risk.

Some recent studies suggest that a reversion of the mesenchymal phenotype of malignant cells may facilitate the establishment of macroscopic metastases [22], [25], [28].