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Neoplastic lesions: Patients with highly evolved perianal disease may develop malignant lesions such as anal squamous carcinoma or adenocarcinoma of the distal rectum, but the risk for such neoplasia seems quite low.
Patients with liver metastases may develop malignant carcinoid syndrome, releasing vasoactive substances into the systemic circulation.
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p27Kip1 haplo-insufficiency and deficiency stimulate MNU-induced prostate carcinogenesis, suggesting that PIN in human prostate lacking partial or total p27Kip1 expression may have a higher potential to progress and develop malignant phenotype than lesions with wild type p27.
A study in the same journal in October 2003 suggested that tanning salon users were 55percentt more likely to develop malignant melanoma.
Outbred companion dogs develop malignant melanoma (CMM) with similar aggressive metastatic traits.
They have yet to develop malignant disease.
Ectopic breast tissue can occur anywhere along the primitive embryonic milk lines and may develop benign and malignant pathologic processes similar to those seen in normally located breast tissue, such as fibroadenoma, intraductal papilloma, fibrocystic disease, lactating adenoma, hidradenoma papilliferum, and carcinoma [2, 3].
Pulmonary metastases may develop along with the malignant bony lesion [24], [35].
Most of these lesions are regarded as benign hyperplastic lesions, but some may develop dysplasia, a pre-malignant neoplastic lesion.
Choroidal melanoma is the most common primary malignant eye tumor, but a variety of other benign and malignant tumors may develop in the eye and pose diagnostic problems [ 2, 3].
3 A significant number of patients with malignant PT may develop local recurrence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com