The presence of YB-1/p18 in plasma samples may indicate malignant disorders of different origin.
However, some other features of the tumor may indicate malignant characteristics, including recurrence, gross local invasion, vascular or capsular invasion, tumor necrosis, malignant histologic pattern, and cellularity [9].
These observations have suggested that the presence of such activity may indicate the malignant potential of a glioma.
FHIT protein deletion or reduction might indicate malignant transformation.
Change in shape, size, or colour of a nevus may indicate transformation into a malignant tumour.
In addition, DNA aneuploidy may indicate the aggressiveness of malignant neoplasms in a variety of organs, including the prostate, breast, urothelial tract, cervix, ovary, lung, skin, and oral mucosa [ 3, 4, 15- 20].
Nevertheless, given that differential CAR expression may indicate a progression step during malignant transformation, these previous findings might reflect the possible complex function of CAR.
However, symptoms including itchiness, bleeding and changes in size or color may indicate that the mole is malignant.
This may indicate a shift to a more malignant phenotype in the present adenoma model following exposure to gastrin.
This latter test was technically easier to perform and could serve to detect persons of increased susceptiability to transformation, since this may indicate an increased risk of natural malignant disease.
Our findings provide new clues into the mechanisms involved in lymphoma progression and may indicate new targets for effective treatment of malignant effusions growing in body cavities.
