Sentence examples for may disrupt endogenous from inspiring English sources

The hypothesis that xenobiotics may disrupt endogenous hormonal signalling has received considerable scientific attention, but human evidence is scarce.

Thus, ectopic overexpression of the BRCA2 fragment containing intact CHEK2 phosphorylation sites may disrupt endogenous gene product function, leading to chromosomal instability.

Although successful at enriching for rare cell types, the drawback of invasive cell-purification techniques is that they require extensive tissue manipulation that may disrupt endogenous patterns of gene expression.

RNA polymerase III (Pol III) transcription regulatory elements have been used successfully but a concern has been that overproduction of anti-HBV shRNAs may disrupt endogenous miRNA function [ 43].

The present study hypothesizes that phytoestrogen exposure of female Siamese fighting fish (Betta splendens) may disrupt endogenous steroid levels, change agonistic behavior expression, and potentially also disrupt oocyte development.

The possible involvement of the AhR, as well as other target receptors, in endogenous functions suggest that xenobiotic ligands may disrupt these endogenous functions and/or lead to additional toxic effects.

Sometimes, transgenes disrupt endogenous genes by homologous recombination.

In fact, COX-2 inhibitors are able to disrupt endogenous resolution mechanisms.

We utilized TAT-TALEN to successfully disrupt endogenous CCR5 in HeLa cells and hiPSCs.

Thus, it is feasible to use synthetic peptides to disrupt endogenous complexes between AnxA2 and S100A10 in vivo (Table  2).

To clarify the functional role of SFRP inactivation in breast cancer, we used siRNA to disrupt endogenous SFRP1 expression.