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Further disruption of actin filaments may disrupt normal bile export pump function, causing cholestasis (Lee 2003).
However, their prolonged interaction with living organisms may disrupt normal activity leading to malfunctioning and diseases.
Hence, falling into the "similarity trap" may disrupt normal BRCA1 and p53 functions.
Consequently, reduction of these factors could facilitate drinking behaviors in adolescents, which may disrupt normal developmental processes.
Since MAPK dependent pathways play a crucial role during pregnancy, non-physiological activation by Cd exposure may disrupt normal functions in trophoblast cells.
These results suggest dysfunctional SOCE regulation (Figure 7) may disrupt normal Ca2+ homeostasis and therefore play a significant role in ADPKD.
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In some cases, substances other than sex steroids may also disrupt normal sexual development.
Conditions that affect the spinal cord (multiple sclerosis, disc herniation) may also disrupt normal micturition reflexes, resulting in OAB.
Thus, the inhibitory effects of PBDEs observed in our study could be due to their action on TR-mediated gene expression in Purkinje cells and may consequently disrupt normal brain development.
Based on these findings, we proposed that abnormal regulation of miRNAs and protein-coding genes by ECs may eventually disrupt normal signal transduction pathways or destroy the dosage balance of protein complexes.
Because TH also tightly regulates fundamental gene expression both directly and indirectly, not only in the cerebellum but also in other brain regions (Koibuchi et al. 1999, 2001), the inhibitory effects of PBDEs on TR-mediated gene expression may widely disrupt normal brain development via TH-dependent gene regulations.
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