Exogenous epinephrine may alter the endogenous norepinephrine metabolism in septic patients.
Thus, environmental chemicals that are endocrine disruptive, or that mimic or alter endogenous hormonal activity, may plausibly affect endometriosis risk.
While the likelihood of altering the safety of transgenic crops through DNA-insertional effects may be lower than for traditional breeding [ 16, 18, 20, 22, 39], the safety assessment for new transgenic crops bearing traits intended to alter endogenous metabolic pathways may be aided by hypothesis-driven compositional analyses.
Moreover, when compared to males, post-menopausal older females may have altered endogenous opioid systems, which place them at an increased risk of chronic pain and pain-related disability (e.g., avoidance, functional decline).
Forced huTIMP-3 expression did not alter endogenous muTIMP-3 expression (Figure S1B).
These findings suggest that other phytohormones and abiotic stress factors might alter endogenous auxin levels.
These results suggest that the insertion of a new transgene in a single GM plant may alter the expression of endogenous genes, especially those related to energetic metabolism, since the transgene are being expressed constantly in the plant tissues and, therefore, demand high levels of energy.
An increase or decrease in activity of these enzymes may alter the level of endogenous estrogen (estradiol), thereby influencing susceptibility to breast cancer [ 5, 6].
