Given our findings of the important role tumor-specific CD4 T cells play in augmenting therapy, combining CD8+ T-cell adoptive immunotherapy with vaccination that includes targets with CD4+ epitopes may be a good way to induce endogenous tumor-specific CD4+ helper T-cell responses.
Both of these treatments induce endogenous AF synthesis [ 28].
Under that model, indirect effect of the CDT may induce the production of endogenous DNAses converging to DNA fragmentation [7].
Departure from the horizontal position may induce asymmetric distribution of endogenous growth substances (e.g. auxins) in the new buds of fragments, and make them reorient toward the vertical due to gravity stimulation [13], [14].
Second, the repeat RNA may induce toxicity by sequestering endogenous RNA-binding proteins in nuclear RNA foci [ 16].
Thus, while enterobacterial and Ft LPS differ in molecular targets (i.e., TLR4 versus TLR2, respectively) and their ability to induce inflammatory cytokines, both types of LPS may induce the generation of endogenous PPAR agonists as a mechanism of down-regulating inflammation.
Various studies indicate that polyphenols may induce the upregulation of endogenous antioxidant enzymes and cytoprotective proteins such as quinone oxidoreductase-1, SOD, glutathione S-transferase, glutathione peroxidase, and heme oxygenase-1 hence exerting also an indirect antioxidant effect in addition to direct radical scavenging [ 283, 284].
Reduction of mitochondrial respiration enhances cancer to exhibit more aggressive phenotypes suggesting that endogenous normoxia-induced prenylation may induce a more aggressive phenotype of cancer.
This endogenous steroid may induce negative mood in sensitive women when present in serum levels comparable to the premenstrual phase.
Oxygen radicals generated by environmental agents and endogenous processes may induce damage to DNA (Halliwell 1994).
