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Labeling methods using chemicals may affect stem cell functions [ 7], and most fail to fluoresce for a long period owing to photobleaching [ 12].
The transpirational xylem stream supplies inorganic nutrients (and water) to bark chlorenchyma (Pfanz 2008), so if the xylem stream is disrupted it may affect stem photosynthesis.
Considering that TGF-β1 is broadly produced, and signals to a variety of cells, the age-related and evolutionarily conserved elevation of its functional levels in old sera may affect stem cell responses in various other tissues.
It would be interesting to ascertain relevant activities in the mammary gland as a tissue subjected to a wide range of hormonal changes and where paracrine interactions may affect stem cell fate.
Taken together these observations have suggested that damage caused by a dysregulation in the glucose level tolerance may affect stem cell properties in a long term and irreversible fashion.
Similar(55)
Pharmacological modulation of nuclear calcium or modulation of gene expression levels of proteins involved in this process may directly affect stem cell differentiation during development [ 58].
Although the mechanisms have not been fully discerned, and only HH signaling was studied in this research, other signaling pathways may also affect stem cell differentiation.
Moreover, the growth advantage was most pronounced in the first 5 days of culture when the cells are the least differentiated, suggesting that the 126/KD phenotype may specifically affect stem and early progenitor cells, reflecting the physiological expression pattern of miR-126.
Alternatively, mtDNA mutations may not directly affect stem cell function but may only act at the point of early stem cell differentiation, leading to the production of abnormal progeny cells and a loss of somatic tissue maintenance (Fig. 1).
Moreover, it should be considered that the lack or a defective function of one specific ECM component may not directly affect stem cell behavior, as on the one hand it may generate side effects acting indirectly on stem cells and on the other hand such effects could be masked by compensatory mechanisms.
Inflammation may affect mesenchymal stem cells in synovial fluid.
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