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Exact(19)
In summary, this study demonstrates the potential for gene expression profiling to identify toxic hazards by the identification of mechanistically relevant markers of toxicity.
Microarrays have the potential to significantly impact our ability to identify toxic hazards by the identification of mechanistically relevant markers of toxicity.
Current trials have also incorporated biologic surrogate markers of toxicity and outcome such as drug levels and neuroimaging.
Acetylcholinesterase (AChE) and lactate dehydrogenase (LDH) activities as well as lipid peroxidation (LP) levels were measured in several tissues as general markers of toxicity.
In this process, biomarkers for toxicity are as relevant as those for efficacy, and intense efforts in developing more specific and sensitive biomarkers for liver or renal toxicity of drugs, for example, are being undertaken, partially leading to approved novel markers of toxicity.
Strategies need to urgently be developed to avoid important CSDIs, to identify early markers of toxicity and to manage unavoidable interactions safely in order to reduce risk of harm, and to maximize the effectiveness of mass antiretroviral deployment in Africa.
Similar(41)
One strategy involves phenotypic anchoring of gene expression changes to identify molecular mechanisms and candidate bio-markers of toxicity (i.e., single genes, proteins, or biological pathways).
Animal weight was monitored as a marker of toxicity.
Urinary retention can therefore not then be used as a marker of toxicity.
It is controversial whether or not formate, the main metabolite responsible for methanol's acute toxicity, is a sensitive biological marker of toxicity or exposure.
Moreover, as there is neither a marker of toxicity nor of efficacy for cisplatin-based IPC, IPCL could be useful in this context.
Related(20)
manifestations of toxicity
parameters of toxicity
markers of impairment
markers of exposure
markers of effect
markers of dose
indicator of toxicity
markers of acute
markers of poisoning
markers of closeness
markers of status
markers of rhythm
markers of experience
markers of cell
markers of inflammation
markers of lifestyle
markers of power
markers of home
markers of liver
markers of success
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