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However, the true identity of these cells remains obscure largely due to the lack of specific bona fide antigenic markers for stem versus progenitor cells.
Therefore, the development of genetic markers for stem cell identification might constitute a valuable tool for improving the efficiency of GCT.
In the present study, B10 as a clonal cell line originated from a single human MSC, expresses Oct-4 and ABCG2 as general markers for stem cells, nestin as a neural stem cell marker, and Mash-1 and Otx-2 which are basic helix-loop-helix (bHLH) transcription factors important in developmental process of neurogenesis.
EPCs express markers for stem cells, including CD34, CD133, and the endothelial cell marker vascular endothelial growth factor receptor 2 (VEGFR2) (16, 16), whereas CPCs only have markers for stem cells.
MSCs were characterized by morphology and expression of specific markers for stem cells, pluripotency, inflammation, and cell cycle.
Most important among these are markers for stem cells and armed with such markers, single-cell analysis does allow the inspection of rare subpopulations [ 2].
Similar(49)
Two recent studies identified CD133 as a marker for stem cells in colorectal cancers (CRC) [8], [9].
p63, another marker for stem cells or basal cells, was used here as the positive control.
It was originally regarded as a marker for stem and progenitor cells of the hematopoietic system [ 31, 32].
Recently, GD2, a disialoganglioside has been identified as a marker for stem cells of MSCs [ 10] and breast cancer [ 11].
We and several other labs have shown that it is a marker for stem cells in many tissues.
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