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Using both a chromosome-based cladistic analysis as well as by mapping of chromosomal differences onto a molecular-based phylogenetic tree, we revealed a number of potential cytogenetic signatures that support the clade of Pandionidae (PHA) + Accipitridae.
Snyder's laboratory at Yale specializes in the large-scale analysis of proteins using microarrays and global mapping of chromosomal protein binding sites.
To understand the role of DSBs in multiple cellular mechanisms, a robust method for genome-wide mapping of chromosomal breaks at one-nucleotide resolution is required.
In this work, we report a fine mapping of chromosomal imbalances in a set of 27 BL primary tumors and cell lines.
Thus, based on genome wide SNP arrays, fine mapping of chromosomal breakpoints and subsequent identification of the specific genes recurrently altered (deleted, gained or amplified) is achieved for individual samples.
Combined with ongoing efforts to map chromatin binding proteins and long distance interactions by 3C techniques genome-wide, mapping of chromosomal attachments to a nuclear substructure may lead to a better understanding of gene regulation and the identification new gene regulatory elements.
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Our results form the first global map of chromosomal interactions in a eukaryotic nucleus and demonstrate the highly connected nature of the yeast genome.
Both techniques rely heavily on detailed maps of chromosomal regions, initially to understand the scope of the regions being modified and finally to provide the cloned resources necessary to allow both finished sequencing and large insert complementation.
The INDEL genotyping enabled fast coarse-mapping of chromosomal regions containing QTL, thus providing an efficient means for characterization of genetic architecture in multiple crosses and large pedigrees.
Plasmid map of chromosomal knock-in vector in C. bescii for extracellular expression of E1 (Acel0614).
High-throughput technologies can effectively replace cytogenetics to generate high-resolution maps of chromosomal aberrations.
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